Icsi Centres in Delhi

Male infertility may be due to:

·         A decrease in sperm count

·         Sperm being blocked from being released

·         Sperm that do not work properlyMale infertility can be caused by:

·         Environmental pollutants

·         Being in high heat for prolonged periods

·         Birth defects

·         Heavy use of alcohol, marijuana, or cocaine

·         Too little or too much hormones

·         Impotence

·         Infection

·         Older age

·         Cancer treatments, including chemotherapy and radiation

·         Scarring from sexually transmitted diseases, injury, or surgery>

·         Surgery to prevent pregnancy (vasectomy), or failure of vasectomy reversal

·         Retrograde ejaculation

·         Smoking

o    Diabetes mellitus thyroid disorders, adrenal disease

Hypothalamic-pituitary factors

o    Hyperprolactinemia

o    Hypopituitarism

o    The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1.5 and 95% confidence interval of 1.1–2.0.

·         Use of certain drugs, such as cimetidine, spironolactone, and nitrofurantoin

·         Environmental factors

o    Toxins such as glues, volatile organic solvents or silicones, physical agents, chemical dusts, and pesticides. Tobacco smokers are 60% more likely to be infertile than non-smokers.

o    ICSI or Intracytoplasmic sperm Injection is offered to a couple when the semen sample does not fall within ‘normal’ parameters. This can be due to:

§  Oligozoospermia – Low number of sperm in the ejaculate

§  Asthenzoospermia – Poor progression or movement of the sperm

§  Teratozoospemia – High numbers of abnormally formed sperm

ICSI Treatment in India with Progeny IVF-ICSI CENTER Delhi

The ICSI fertility treatment is especially helpful in reproductive medicine,making fatherhood possible for men with sperm disorders. If a sperm fails to fertilize the egg naturally or during IVF, this is usually because the sperm fails to penetrate the egg’s outer and inner membrane.

Intra Cytoplasmic Sperm Injection (ICSI) is the injection of a single sperm directly into the cytoplasm of the egg.

Who requires ICSi

Patient who have low sperm count, very poor motility or a high percentage.

.

What is ICSI?

·         What is ICSI? ICSI is an acronym for intracytoplasmic sperm injection

·         ICSI is a very effective method to fertilize eggs in the IVF lab after they have been aspirated from the female

·         Its main use is for significant male infertility cases

·         IVF with ICSI involves the use of specialized micromanipulation tools and equipment and inverted microscopes that enable embryologists to select and pick up individual sperm in a specially designed ICSI needle.

·         The needle is carefully advanced through the outer shell of the egg and the egg membrane – and the sperm is injected into the inner part (cytoplasm) of the egg.

·         This usually results in normal fertilization in about 75-85% of eggs injected with sperm.

·         However, first the woman must be stimulated with medications and have an egg retrieval procedure so we can obtain several eggs for in vitro fertilization and ICSI.

Who should be treated with intracytoplasmic sperm injection?

There is no “standard of care” in this field of medicine regarding which cases should have the ICSI procedure and which should not. Some clinics use it only for severe male factor infertility, and some use it on every case. we at progeny ivf icsi clinic are doing ICSI for all patients undergoing IVF treatment as our embryologist Sudesh Kamat IS THE FIRST EMBRYOLOGIST TO GIVE FIRST ICSI BABY TO INDIA in 1992 . HE IS DOING 10-30 ICSI CASES EVERY DAY TRULY SPEAKING HE HAS MAGIC IN HIS HANDS .The large majority of IVF clinics are somewhere in the middle of these 2 extremes.

Common reasons used for performing ICSI

·         Severe male factor infertility that do not want donor sperm insemination.

·         Couples with infertility with:
o Sperm concentrations of less than 15-20 million per milliliter
o Low sperm motility – less than 35%
o Very poor sperm morphology (subjective – specific cutoff value is debatable)

·         Having previous IVF with no fertilization – or a low rate of fertilization (low percentage of mature eggs that were normally fertilized).

·         Sometimes it is used for couples that have a low yield of eggs at egg retrieval. In this scenario, ICSI is being used to try to get a higher percentage of eggs fertilized than with conventional insemination of the eggs (mixing eggs and sperm together).

How is ICSI performed?

·         The mature egg is held with a specialized holding pipette.

·         A very delicate, sharp and hollow needle is used to immobilize and pick up a single sperm.

·         This needle is then carefully inserted through the zona (shell of the egg) and in to the center (cytoplasm) of the egg.

·         The sperm is injected in the cytoplasm and the needle is removed.

·         The eggs are checked the next morning for evidence of normal fertilization.

Fertilization and pregnancy success rates with ICSI

Fertilization rates for ICSI: Most IVF programs see that about 70-85% of eggs injected using ICSI become fertilized. We call this the fertilization rate, which is different from the pregnancy success rate.

Pregnancy success rates for in vitro fertilization procedures with ICSI have been shown in some studies to be higher than for IVF without ICSI. This is because in many of the cases needing ICSI the female is relatively young and fertile (good egg quantity and quality) as compared to some of the women having IVF for other reasons.

In other words, the average egg quantity and quality tends to be better in ICSI cases (male factor cases) because it is less likely that there is a problem with the eggs – as compared to cases with unexplained infertility. Some unexplained cases have reduced egg quantity and/or quality – which lowers the chances for a successful IVF outcome

Sometimes IVF with ICSI is done for “egg factor” cases – low ovarian reserve situations. This is when there is either a low number, or low “quality”of eggs (or both). In such cases, ICSI fertilization and pregnancy success rates tend to be lower.

·         This is because the main determinant of IVF success is the quality of the embryos.

·         The quality of the eggs is a crucial factor determining quality and viability of embryos.
In some cases, assisted hatching is done on the embryos prior to transfer, in order to maximize chances for pregnancy

Looking for Fertility treatment in India, send you medical and pregnancy history to info@ivfprogeny.com for a free online consultation.